Exhibit 5.1 

April 28, 2025

RE: Alpha Tau Medical Ltd.

Ladies and Gentlemen:

We have acted as Israeli counsel to Alpha Tau Medical Ltd, a company organized under the laws of the State of Israel (the “Company”), in connection with the offer, issuance and sale of 14,110,121 ordinary shares, no par value per share (the “Ordinary Shares”) to the Purchaser (as defined in the Purchase Agreement) in a registered direct offering (the “Offering”) pursuant to the Share Purchase Agreement, between the Company and the Purchaser, dated April 24, 2025 (the “Purchase Agreement”). The Offering is being effected pursuant to a Registration Statement on Form F-3 (File No. 333-271073) (the “Registration Statement”), filed by the Company with the Securities and Exchange Commission (the “Commission”), the base prospectus, dated April 13, 2023, forming a part thereof (the “Base Prospectus”), the prospectus supplement, dated April 24, 2025, in the form filed with the Commission on April 28, 2025 (the “Prospectus Supplement” and together with the Base Prospectus, the “Prospectus”).

This opinion letter is furnished to you at your request to enable you to fulfill the requirements of Item 601(b)(5) of Regulation S-K under the Securities Act, in connection with the filing of the Registration Statement.

In connection herewith, we have examined the originals, or photocopies or copies, certified or otherwise identified to our satisfaction, of: (i) the Registration Statement; (ii) the Base Prospectus; (iii) the Prospectus Supplement; (iv) the Purchase Agreement; (v) the articles of association of the Company, as currently in effect (the “Articles”); (vi) resolutions of the board of directors (the “Board”) of the Company which have heretofore been approved and relate to the Registration Statement, the Prospectus and other actions to be taken in connection with the Offering; and (vii) such other corporate records, agreements, documents and other instruments, and such certificates or comparable documents of public officials and of officers of the Company as we have deemed relevant and necessary as a basis for the opinions hereafter set forth. We have also made inquiries of such officers as we have deemed relevant and necessary as a basis for the opinions hereafter set forth.

In such examination, we have assumed the genuineness of all signatures, the legal capacity of all natural persons, the authenticity of all documents submitted to us as originals, the conformity to original documents of all documents submitted to us as certified copies or confirmed as photostatic copies, and the authenticity of the originals of such latter documents. We have also assumed the truth of all facts communicated to us by the Company and that all minutes of meetings of the Board and the shareholders of the Company that have been provided to us are true and accurate and have been properly prepared in accordance with the Articles and all applicable laws.

On the basis of the foregoing, and in reliance thereon, we are of the opinion that the Ordinary Shares issued in the Offering are validly issued, fully paid and non-assessable. 

Members of our firm are admitted to the Bar in the State of Israel, and we do not express any opinion as to the laws of any other jurisdiction. This opinion is limited to the matters stated herein and no opinion is implied or may be inferred beyond the matters expressly stated.

We consent to the filing of this opinion as an exhibit to the Registration Statement (as an exhibit to a Report of Foreign Private Issuer on Form 6-K that is incorporated by reference in the Registration Statement) and to the reference to our firm appearing under the caption “Legal Matters” in the Prospectus. In giving this consent, we do not thereby admit that we are within the category of persons whose consent is required under Section 7 of the Securities Act, the rules and regulations of the Commission promulgated thereunder or Item 509 of the Commission’s Regulation S-K under the Securities Act.

This opinion letter is rendered as of the date hereof and we disclaim any obligation to advise you of facts, circumstances, events or developments that may be brought to our attention after the date of the Registration Statement that may alter, affect or modify the opinions expressed herein.