UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

Form 6-K

Report of Foreign Private Issuer

Pursuant to Rule 13a-16 or 15d-16

under the Securities Exchange Act of 1934

For the month of May 2025

Commission file number: 001-42375

Polyrizon Ltd.

(Translation of registrant’s name into English)

5 Ha-Tidhar Street

Raanana, 4366507, Israel

(Address of principal executive offices)

Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F.

Form 20-F ☒ Form 40-F ☐

CONTENTS

Following the effectiveness of the registration statement on Form F-1 (Registration No. 333-286849) on May 12, 2025, filed by Polyrizon Ltd. (the “Company”), relating to the resale by selling shareholders identified therein of the Company’s ordinary shares, with no par value (the “Ordinary Shares”), including Ordinary Shares issuable upon exercise of warrants, such selling shareholders have been exercising their warrants.

As a result of such exercises, the number of issued and outstanding Ordinary Shares as of the end of business on May 14, 2025, was 349,692,746.

This Form 6-K is incorporated by reference into the Registrant’s Registration Statement on Form S-8 (File No. 333-284410), filed with the Securities and Exchange Commission, to be a part thereof from the date on which this report is submitted, to the extent not superseded by documents or reports subsequently filed or furnished.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

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