February 19, 2026 Fourth-Quarter 2025 Earnings Presentation

Forward Looking Statements The forward-looking statements in this presentation are based upon the Company’s current expectations and beliefs, and involve known and unknown risks, uncertainties and other factors, which may cause the Company’s actual results, performance and achievements and the timing of certain events to differ materially from the results, performance, achievements or timings discussed, projected, anticipated or indicated in any forward-looking statements. Such risks, uncertainties and other factors include, among others, the following: failure to continue to successfully commercialize ARIKAYCE® in the U.S., Europe or Japan or failure to successfully commercialize BRINSUPR®I in the U.S. or Europe, or to maintain U.S., European or Japanese approval for ARIKAYCE or U.S. or E.U. approval for BRINSUPRI; our inability to obtain full approval of ARIKAYCE from the FDA, including the risk that we will not successfully or in a timely manner complete the confirmatory post-marketing clinical trial required for full approval of ARIKAYCE, or our failure to obtain regulatory approval to expand ARIKAYCE’s indication to a broader patient population; failure to obtain, or delays in obtaining, regulatory approvals for our product candidates in the U.S., Europe or Japan, for ARIKAYCE outside of the U.S., Europe and Japan, including separate regulatory approval for the Lamira® Nebulizer System in each market and for each usage, or for BRINSUPRI outside of the U.S. and the E.U.; failure to successfully commercialize our product candidates, if approved by applicable regulatory authorities, or to maintain applicable regulatory approvals for such product candidates, if approved; uncertainties or changes in the degree of market acceptance of our marketed products or, if approved, our product candidates, by physicians, patients, third-party payors and others in the healthcare community; our inability to obtain and maintain adequate reimbursement from government or third-party payors for our marketed products or, if approved, our product candidates, or acceptable prices for our marketed products or, if approved, our product candidates; inaccuracies in our estimates of the size of the potential markets for our marketed products and our product candidates or in data we have used to identify physicians, expected rates of patient uptake, duration of expected treatment, or expected patient adherence or discontinuation rates; failure of third parties on which we are dependent to manufacture sufficient quantities of our marketed products and our product candidates for commercial or clinical needs, as applicable, to conduct our clinical trials, or to comply with our agreements or laws and regulations that impact our business; risks and uncertainties associated with, and the perceived benefits of, our senior secured loan with certain funds managed by Pharmakon Advisors, LP and our royalty financing with OrbiMed Royalty & Credit Opportunities IV, LP, including our ability to maintain compliance with the covenants in the agreements for the senior secured loan and royalty financing and the impact of the restrictions on our operations under these agreements; our inability to create or maintain an effective direct sales and marketing infrastructure or to partner with third parties that offer such an infrastructure for distribution of our marketed products or any of our product candidates that are approved in the future; failure to successfully conduct future clinical trials for our marketed products or our product candidates and our potential inability to enroll or retain sufficient patients to conduct and complete the trials or generate data necessary for regulatory approval of our product candidates or to permit the use of ARIKAYCE in the broader population of patients with MAC lung disease, among other things; development of unexpected safety or efficacy concerns related to our marketed products or our product candidates; risks that our clinical studies will be delayed, that serious side effects will be identified during drug development, or that any protocol amendments submitted will be rejected; failure to successfully predict the time and cost of development, regulatory approval and commercialization for novel gene therapy products; risk that interim, topline or preliminary data from our clinical trials that we announce or publish from time to time may change as more patient data become available or may be interpreted differently if additional data are disclosed, or that blinded data will not be predictive of unblinded data; risk that our competitors may obtain orphan drug exclusivity for a product that is essentially the same as a product we are developing for a particular indication; our inability to attract and retain key personnel or to effectively manage our growth; our inability to successfully integrate our acquisitions and appropriately manage the amount of management’s time and attention devoted to integration activities; risks that our acquired technologies, products and product candidates will not be commercially successful; inability to adapt to our highly competitive and changing environment; inability to access, upgrade or expand our technology systems or difficulties in updating our existing technology or developing or implementing new technology; risk that we are unable to maintain our significant customers; risk that healthcare legislation or other government action materially adversely affects our business; business or economic disruptions due to catastrophes or other events, including natural disasters or public health crises; risk that our current and potential future use of AI and machine learning may not be successful; deterioration in general economic conditions in the U.S., Europe, Japan and globally, including the effect of prolonged periods of inflation, affecting us, our suppliers, third-party service providers and potential partners; risk that we could become involved in costly intellectual property disputes, be unable to adequately protect our intellectual property rights or prevent disclosure of our trade secrets and other proprietary information, and incur costs associated with litigation or other proceedings related to such matters; restrictions or other obligations imposed on us by agreements related to our marketed products or our product candidates, including our license agreements with PARI and AstraZeneca AB, and failure to comply with our obligations under such agreements; the cost and potential reputational damage resulting from litigation to which we are or may become a party, including product liability claims; risk that our operations are subject to a material disruption in the event of a cybersecurity attack or issue; changes in laws and regulations applicable to our business, including any pricing reform and laws that impact our ability to utilize certain third parties in the research, development or manufacture of our product candidates, and failure to comply with such laws and regulations; our history of operating losses, and the possibility that we never achieve or maintain profitability; goodwill impairment charges affecting our results of operations and financial condition; inability to repay our existing indebtedness and uncertainties with respect to our ability to access future capital; and delays in the execution of plans to build out an additional third-party manufacturing facility approved by the appropriate regulatory authorities and unexpected expenses associated with those plans. Additional Disclaimers: Please be aware that TPIP, brensocatib in HS, INS1201, INS1202, INS1148, and INS1033 are investigational products that have not been approved for sale or found safe or effective by the FDA or any regulatory authority. In addition, ARIKAYCE has not been approved for the treatment of all patients with MAC lung disease and brensocatib has not been approved for the treatment of patients with non-cystic fibrosis bronchiectasis outside the U.S. and the E.U. This presentation is not promotion or advertisement of ARIKAYCE, BRINSUPRI, TPIP, brensocatib in HS, INS1201, INS1202, INS1148, or INS1033. Insmed, ARIKAYCE and BRINSUPRI are registered trademarks of Insmed Incorporated. All other trademarks are property of their respective owner(s). HS: Hidradenitis Suppurativa | TPIP: Treprostinil Palmitil Inhalation Powder | MAC / MAC LD: Mycobacterium avium complex lung disease | FDA: Food & Drug Administration

Opening Remarks Commercial Updates TPIP Updates Financial Results 5-6 8-13 15-16 19-21 Will Lewis Chair & CEO Sara Bonstein Chief Financial Officer

Opening Remarks Will Lewis | Chair & CEO

2025 Set the Commercial and Clinical Foundation Upon Which 2026 is Expected to Accelerate 2025 Accomplishments Commercial Clinical FDA Approval of BRINSUPRI® U.S. BRINSUPRI Launch Double-Digit Global ARIKAYCE® Growth Positive Ph2 TPIP Data in PAH GTx for DMD & ALS Entered Clinic Acquired Ph2-Ready INS1148 2026 Priorities Accelerate & Expand U.S. BRINSUPRI Launch Deliver Continued ARIKAYCE Growth Invest in First- or Best-in-Class Therapies Expand Pipeline via BD FDA: Food and Drug Administration | U.S.: United States | Ph: Phase | GTx: Gene Therapies | DMD: Duchenne muscular dystrophy | ALS: amyotrophic lateral sclerosis | BD: business development

Anticipate Full-Year Total Company Revenues to More Than Double in 20261 At Least $1 Billion Full-Year 2026 Guidance $450 to $470 Million Full-Year 2026 Guidance 1 2026 revenue guidance for BRINSUPRI and ARIKAYCE as of February 2026 implies full-year company-wide revenues of at least $1.45B, which would represent an increase of ~139% versus full-year 2025 company-wide revenues of $606.4M | BD: business development Confident that cash flow positivity can be achieved without raising capital May raise capital to support BD or other value-creating initiatives

Commercial Updates Will Lewis | Chair & CEO

Launch Trajectory Remains Encouraging Following Strong First Full Quarter Performance U.S. Net Revenues1 ~$144.6M Q4 20251 1 Unaudited revenues for three months ended December 31, 2025 | M: million Revenue performance surpassed high bar set by comparable respiratory launches Commercial team continues to execute at a very high level BRINSUPRI on track to become one of the most successful specialty respiratory launches ever

DIAGNOSED NCFB PATIENTS ON U.S. LABEL FOR BRINSUPRI (500K) 250K (2+ PE) 250K (<2 PE) Initial U.S. TAM $5B+ Peak Sales Multiple Opportunities to Potentially Expand Initial U.S. TAM 1 Flume PA, et al. ERJ Open Res. 2023;9(4):00021-2023. | 2 COPD & asthma patients with comorbid NCFB not currently counted in the 500K diagnosed NCFB U.S. population | NCFB: non-cystic fibrosis bronchiectasis | PE: pulmonary exacerbations in prior 12-month period | COPD: chronic obstructive pulmonary disease | U.S.: United States | TAM: total addressable market | K: thousand | M: million | B: billion | Note: References related to patient TAMs can be found in the Company's Investor Presentation. Outside Currently Diagnosed Population Comorbid undiagnosed NCFB patients2 could contribute substantial upside if diagnosed Efforts underway to quantify undiagnosed opportunity and encourage assessment of potential NCFB Within Currently Diagnosed Population 2-year study suggests ~9% conversion rate from <2 PE to 2+ PE category in 2nd year1 Any conversion would represent upside to potential $5B+ peak sales Expansion Drivers: COPD OR ASTHMA PATIENTS (U.S.) 32M POTENTIAL NCFB PATIENTS IF DIAGNOSED

Positive Launch Feedback Positions BRINSUPRI for Broader Adoption Over Time Physician Behavior What We’re Seeing Potential Impact Potential for increased NCFB screening of exacerbating COPD & asthma patients Expansion Potential signals of increased diagnoses expected 2027+ Monitoring for signs of diagnosis expansion over time Positive feedback from early patients could deepen Rx tendencies Adoption Positive feedback from early physicians & patients Positive experiences could drive increased Rx Broad physician base Rx to limited patients given new mechanism Exploration Nearly half of cumulative prescribers have only written one script1 Positive feedback expected to influence willingness to Rx more broadly Today Next Several Quarters Future 1 ~4,000 cumulative prescribers as of December 31, 2025 | Rx: prescribe / prescribing | NCFB: non-cystic fibrosis bronchiectasis | Q: quarter | COPD: chronic obstructive pulmonary disease

Early Payor Contracting Success Supports Access for a Majority of BRINSUPRI Patients Aligned with pre-launch expectations Among payors requiring additional documentation Offered to payors accepting simple authorization criteria Have access to reimbursement for BRINSUPRI1 >90% Targeted Patient Lives Modest Rebates High Approval Rate Broad Access 1 Either through documented payor policy or medical exception

BRINSUPRI Positioned to Maximize its Commercial Potential v Strong Commercial Conviction Manageable market access dynamics Expect at least $1B in revenues in 2026 Clear path to achieving peak sales goal of $5B+ v Opportunity to Expand TAM Potential to unlock upside in COPD & asthma populations Intend to resource the launch to maximize adjacent patient opportunities 1 Launch metrics as of December 31, 2025 | B: billion | COPD: chronic obstructive pulmonary disease | TAM: total addressable market

ARIKAYCE Demonstrates Continued Strength 1 Growth is vs. same prior year period | GTN: Gross-to-Net | U.S.: United States | Int’l: International | M: Million | * If expanded label for ARIKAYCE is approved | † Total addressable Refractory MAC patients in the U.S., Europe (France, Germany, Italy, Spain, and United Kingdom), and Japan | ‡ Additional addressable MAC patients in the U.S. and Japan if expanded ARIKAYCE label is approved | MAC / MAC LD: Mycobacterium avium complex lung disease | TAM: total addressable market | Note: References related to patient TAMs can be found in the Company's Investor Presentation. U.S. $280.3M +10.0% GTN: ~20% Int’l $153.5M +40.9% FY 20251 ENCORE Topline readout expected March/April Potential Label Expansion* Current TAM 30K† (Refractory MAC) ~+200K‡ Additional Patients* (All MAC LD) Worldwide $433.8M +19.3%

TPIP Updates TPIP: Treprostinil Palmitil Inhalation Powder Will Lewis | Chair & CEO

FDA Grants Treprostinil Palmitil Orphan Drug Designation Potential Clinical Superiority Major Contribution to Patient Care Once-daily therapy with: continuity of parenteral treatment localization of inhaled therapy TPIP Profile Efficacy Placebo-Adjusted Improvement in 6MWD † at Week 161 * Nominally statistically significant in Phase 2 +35.5 meters * vs. same drugs already approved for PAH PAH: pulmonary arterial hypertension | FDA: Food and Drug Administration | TPIP: Treprostinil Palmitil Inhalation Powder | * Nominal p-value not adjusted for multiplicity | † Covariate-adjusted estimate of location shift. Analysis performed using a rank ANCOVA model, adjusting for treatment group, baseline 6-minute walk distance (6MWD), and randomization stratification factors | 1 Measured ~24 hours after dose

Change in baseline exercise capacity (6MWD) at peak exposure (1-3 hours post-dose) Proportion of patients with baseline WHO FC improvement Change in baseline 6MWD at trough exposure (pre-dose) at Week 22 Change in baseline cardiac stress (NT-proBNP concentration) Change in baseline PAH-SYMPACT domain scores Time to clinical worsening2 PALM-PAH (Week 24) Change from baseline in Quality of Life (QoL) Plasma concentrations of TP and treprostinil over time Safety & tolerability3 Primary Endpoint Secondary Endpoints Exploratory Endpoints 1 Participants enrolled in the OLE study will remain on-treatment until Week 104, followed by a 4-week follow-up | 2 Clinical worsening is defined as one of the following: (1) death from any cause,(2) hospitalization for worsening of PAH (≥24 hours), (3) need for atrial septostomy, (4) worsening-related listing for lung and/or heart-lung transplant, (5) need to initiate parenteral therapy with an approved PAH therapy, or (6) deterioration of PAH (defined as a combination of the following changes from baseline: a decrease in 6MWD of ≥15%, confirmed by 2 tests ≥4 hours but not >2 weeks apart, and signs/symptoms of worsened right heart failure or worsened WHO/NYHA FC). All events will be adjudicated by an independent blinded committee. | 3 including AEs, laboratory assessments, vital signs, and 12-lead electrocardiogram | TPIP: Treprostinil Palmitil Inhalation Powder | TP: treprostinil palmitil | PAH: pulmonary arterial hypertension | 6MWD: 6-minute walk distance | OLE: open label extension | NT-proBNP: N-terminal pro b-type natriuretic peptide; a biomarker of cardiac | WHO: World Health Organization | NYHA: New York Heart Association | FC: functional class 4 weeks TPIP 80-1,280 µg inhalation capsules once daily Placebo inhalation capsules once daily Screening Treatment period 24 weeks Baseline End of Study 30 days Follow-up For participants that have not entered the OLE study1 Expect ~344 patients randomized Steady-state period 4-week initial titration to the individual max tolerated dose active : placebo 1:1 End of Treatment Primary Analysis Dose increases allowed up to Week 16 Participants on background sotatercept capped at ~20% of sample size (stratification factor) Phase 3 PAH Trial Designed to Further Evaluate the Efficacy & Tolerability of Once-Daily TPIP Measured at Week 24 unless otherwise specified

Let’s Recap BRINSUPRI launch on track and supports 2026 revenue guidance of at least $1B Robust pipeline of first- or best-in-class* clinical programs poised to contribute catalysts over the next several years Treprostinil palmitil received ODD in PAH; FDA has indicated a single Phase 3 TPIP trial would be sufficient to file, if successful PAH: pulmonary arterial hypertension | FDA: Food and Drug Administration | ODD: Orphan Drug Designation | TPIP: Treprostinil Palmitil Inhalation Powder | B: billion * “Best-in-disease/best-in-class" indicates a profile that could be considered more attractive than other treatment options for a particular disease. Head-to-head clinical trials are not anticipated.

Financial Results Sara Bonstein | Chief Financial Officer

Modest Gross-to-Net Impact Positions Commercial Products For Success In 2026 Revenue At Least $1B $450M to $470M Gross-to-Net Mid-20%s to Low-30%s Low-20%s to Mid-20%s B: billions | M: millions G U I D A N C E G U I D A N C E Full-Year 2026

Strong Capital Position to Support Upcoming Catalysts 1 Cash burn excludes cash received from option exercises as well as ~$70M in non-recurring items attributed to the acquisition of asset INS1148 and a milestone payment to AstraZeneca related to BRINSUPRI’s U.S. approval | 2 Cash burn does not reflect full benefit of BRINSUPRI sales given timing of quarter close | 3 Pending regulatory approvals and the success of current clinical programs | † Unaudited cash, cash equivalents, and marketable securities position as of December 31, 2025 | BD: business development | U.S.: United States ~$1.4B December 31, 2025† In Cash, Cash Equivalents, and Marketable Securities Underlying cash burn1 was similar to prior quarter Only a portion of BRINSUPRI revenues were received in cash as of quarter close2 Expect spending to increase alongside revenue as we resource launches and clinical programs3 Confident cash flow positivity can be achieved without additional capital May raise capital to support BD or other value-creating initiatives

Advancing Commercial and Clinical Programs Through Investment Three Months Ended1 12/31/2025 12/31/2024 Total Revenues $263.8 $104.4 Cost of Product Revenues2 As a % of Revenues (44.2) 16.8% (26.2) 25.0% R&D (254.9) (179.7) SG&A (212.5) (142.5) Other† (72.0) 13.5 Total Operating Expenses $(583.6) $(334.9) Operating Loss $(319.7) $(230.4) Costs2 as % of sales decreased y/y, reflecting BRINSUPRI contribution R&D and SG&A increased y/y reflecting investments in growth: U.S. BRINSUPRI launch Clinical pipeline development 1 Unaudited | 2 Excludes amortization of intangible assets; also referred to as “costs” | † Includes amortization of intangible assets and change in fair value of deferred and contingent consideration liabilities | R&D: research and development | SG&A: selling, general, and administrative expenses | y/y: year-over-year | U.S.: United States (in $ millions, except for percentages)

Closing Remarks Entering 2026 with a strong financial position, enabling the pursuit of our ambitious goals Committed to utilizing our resources to pursue value-creating opportunities Capacity to continue to invest in our commercial portfolio and clinical pipeline to enhance our impact on patients

Q&A Session Will Lewis Chair & CEO Sara Bonstein Chief Financial Officer Martina Flammer Chief Medical Officer